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Oxidative Stress and Hypertension. 2021 Apr 2;128 (7):993-1020. A link between oxidative stress and hypertension has been firmly established in multiple animal models of hypertension but remains elusive in humans. While initial studies focused on inactivation of nitric oxide by superoxide, our understanding of relevant reactive oxygen …
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Conclusions: • Lactose intolerance is a real and important clinical syndrome, but its true prevalence is not known. • The majority of people with lactose malabsorption do not have clinical lactose intolerance. Many individuals who think they are lactose intolerant are not lactose malabsorbers. • Many individuals with real or perceived ...
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Diabetes mellitus is a chronic condition that occurs when the body cannot produce enough or effectively use of insulin. Compared with individuals without diabetes, patients with type 2 diabetes mellitus have a considerably higher risk of cardiovascular morbidity and mortality, and are disproportionately affected by cardiovascular disease.
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The chassis of the FMS FJ40 is a standout feature in its own right, engineered for peak performance in off-road adventures. This robust chassis ensures that the 1/10 scale FJ40 remains steady and reliable, even when tackling challenging landscapes. For extreme rock crawling enthusiasts, the FJ40 is equipped with a compact …
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Background and methods: National surveillance data show recent, marked reductions in morbidity and mortality associated with the acquired immunodeficiency syndrome (AIDS). To evaluate these declines, we analyzed data on 1255 patients, each of whom had at least one CD4+ count below 100 cells per cubic millimeter, who were seen …
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15 15 Veterans Affairs Salt Lake City Health Care System, Salt Lake City, Utah. 16 16 New York University, New York, New York. 17 17 Janssen Pharmaceutica, Beerse, Belgium. 18 18 GlaxoSmithKline, King of Prussia, Pennsylvania; and. 19 19 Odense University Hospital, Odense, Denmark. PMID: 29406779.
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In a phase 2 trial, a twice-yearly injection of inclisiran, a small interfering RNA, was shown to inhibit hepatic synthesis of PCSK9 in adults with heterozygous familial hypercholesterolemia. Methods: In this phase 3, double-blind trial, we randomly assigned, in a 1:1 ratio, 482 adults who had heterozygous familial hypercholesterolemia to ...
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Pharmaceutical synthesis can benefit greatly from the selectivity gains associated with enzymatic catalysis. Here, we report an efficient biocatalytic process to replace a recently implemented rhodium-catalyzed asymmetric enamine hydrogenation for the large-scale manufacture of the antidiabetic comp …
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Abstract: This article describes a 2.1-MHz relaxation oscillator (RxO) for energy-harvesting Internet-of-Things (IoT) sensor nodes. The RxO features an asymmetric swing-boosted RC network and a dual-path comparator to surmount the challenges of sub-0.5-V operation while achieving temperature resilience. The former enables alternating …
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This paper presents an ultra-low-voltage and power-efficient 10 bit hybrid successive approximation register (SAR) analog-to-digital converter (ADC). For reducing the digital-to-analog converter (DAC) capacitance and comparator requirement, we propose a hybrid architecture comprising a coarse 7 bit SAR ADC and fine 3.5 bit time-to-digital …
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This document is an international evidence-based guideline on the diagnosis and management of idiopathic pulmonary fibrosis, and is a collaborative effort of the American Thoracic Society, the European Respiratory Society, the Japanese Respiratory Society, and the Latin American Thoracic Association …
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letts t and x were affected, 2 miuntes later tyz were affected, the answer: an unexplaned pool of water under the keyboard. short circiting the board. had to go back to my cheap horrible basic board untill i dry out the other . Upvote 0 Downvote. K. Katie_20 Commendable. Nov 13, 2016 1 0
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This article describes a highly energy-efficient Wheatstone bridge temperature sensor. To maximize sensitivity, the bridge is made from resistors with positive (silicided diffusion) and negative (poly) temperature coefficients. The bridge is balanced by a resistive (poly) FIR-DAC, which is part of a 2nd-order continuous-time …
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Aims: To appraise the clinical and genetic evidence that low-density lipoproteins (LDLs) cause atherosclerotic cardiovascular disease (ASCVD). Methods and results: We assessed whether the association between LDL and ASCVD fulfils the criteria for causality by evaluating the totality of evidence from genetic studies, prospective …
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Newborn screening (NBS) for cystic fibrosis (CF) is increasingly being implemented and is soon likely to be in use throughout the United States, because early detection permits access to specialized medical care and improves outcomes. The diagnosis of CF is not always straightforward, however. The s …
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Background: In current international guidelines, intraaortic balloon counterpulsation is considered to be a class I treatment for cardiogenic shock complicating acute myocardial infarction. However, evidence is based mainly on registry data, and there is a paucity of randomized clinical trials. Methods: In this randomized, prospective, open …
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The relative bioavailability of ramipril nanoemulsion to that of conventional capsule form was found to be 229.62% whereas to that of drug suspension was 539.49%. The present study revealed that ramipril nanoemulsion could be used as a liquid formulation for pediatric and geriatric patients and can be formulated as self-nanoemulsifying drug ...
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C.R. and P. Dorinsky were involved in conception/design, the acquisition of data, and data interpretation. This article has a related editorial . This article has an online supplement, which is accessible from this issue's table of contents at .
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Based on published prevalence studies, we used two different methodologies to project the number of individuals with Parkinson disease (PD) in Western Europe's 5 most and the world's 10 most populous nations. The number of individuals with PD over age 50 in these countries was between 4.1 and 4.6 million in 2005 and will double to between 8.7 ...
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Zinc, an essential micronutrient, has a cancer preventive role. Zinc deficiency has been shown to contribute to the progression of esophageal cancer. Orai1, a store-operated Ca2+ entry (SOCE) channel, was previously reported to be highly expressed in tumor tissues removed from patients wi …
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Email Us or call (877) 774-4751 or (716) 773-9300 (Outside US) or find your local GP:50 Sales Representative using the links below. Looking for pressure sensing transducers or transmitters? View the GP50 NY LTD Product Catalog online now. Contact us or request a quote today on a custom transducer or transmitter.
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